Despite many outstanding advances in medicine, cardiovascular diseases (CVD) are remained as the main global reason for death. CVD is not a certain disease, rather is a class of diseases of heart and blood vessels including: stroke, heart failure, hypertensive heart disease, rheumatic heart disease, cardiomyopathy, heart arrhythmia, congenital heart disease, valvular heart disease, carditis, aortic aneurysms, peripheral artery disease, thromboembolic disease, and venous thrombosis.
According to the 2018 report of World Health Organization (WHO), Cardiovascular diseases (CVDs) take the lives of 17.9 million people every year, 31% of all global deaths. Tobacco use, unhealthy diet and physical inactivity are the most related risk factors for CVD. In contrast, healthy life style which healthy diet is an apparent part of that, can save and extend the lives of CVD patients even near the normal rate.
Regarding to its powerful antioxidant effect, Vitamin C has recently received considerable attention among physicians for its possible role in heart health. Meanwhile, some clinical evidences showed the low plasma level of Vitamin C in patients with heart and vascular failure.
Some fruits and vegetables are enriched in natural Vitamin C and antioxidants and this is well accepted that; the consumption of such fruits and vegetables can help the body to have healthy.
One of the most probable mechanism of Vitamin C in heart protection is by metabolic balance through regulation in lipid metabolism which will affect the normal physiology of the heart and vascular system. For instance, Vitamin C inhibits the oxidation of LDL-protein. By inhibition of attachment of oxidized LDL to scavenger receptors through the endothelial of arteries. Vitamin C has shown to have the ability to decrease the risk of artery hardening (atherosclerosis).
Among different modalities for heart protection, Linus Pauling's specific therapy for cardiovascular and heart diseases is high dosages of two essential nutrients; Vitamin C and the amino acid lysine. Vitamin C has ability to prevent apoptosis of vascular smooth muscle cells, through which can help to keep the plaques more stable and not growing in case of atherosclerosis.
There are some clinical practice with enough sample size of CVD patients who received the Vitamin C and results showed the benefit of this intervention to reduce the arterial stiffness in these cases. To derive the beneficial effect, the dose and the duration of treatment are two matters of subject in those receiving Vitamin C. Although it should also be noted that regarding to the importance of bioflavonoids in the pharmacokinetic of Vitamin C it is better to use natural and organic Vitamin C.
Attention:
NOAH Vitamin C is not for prevention, treatment, or diagnosis of diseases.
References
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1- https://www.who.int/cardiovascular_diseases/en
2- Melissa A. Moser, Ock K. Chun. Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies. Int J Mol Sci. 2016 Aug; 17(8): 1328.
3- Joshipura KJ, Hu FB, Manson JE, Stampfer MJ, Rimm EB, Speizer FE, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett WC. The effect of fruit and vegetable intake on risk for coronary heart disease. Ann Intern Med. 2001 Jun 19; 134(12):1106-14.
4- He FJ, Nowson CA, Lucas M, MacGregor GA. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. J Hum Hypertens. 2007 Sep; 21(9):717-28.
5- Salvayre R, Negre-Salvayre A, Camaré C. Oxidative theory of atherosclerosis and antioxidants. Biochimie. 2016 Jun; 125():281-96.
6- Li D, Mehta JL. Oxidized LDL, a critical factor in atherogenesis. Cardiovasc Res. 2005 Dec 1; 68(3):353-4.
7- Siow RC, Richards JP, Pedley KC, Leake DS, Mann GE. Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides. Arterioscler Thromb Vasc Biol. 1999 Oct; 19(10):2387-94.
8- Ashor AW, Siervo M, Lara J, Oggioni C, Mathers JC .Antioxidant vitamin supplementation reduces arterial stiffness in adults: a systematic review and meta-analysis of randomized controlled trials. J Nutr. 2014 Oct; 144(10):1594-602.
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