Cardio
Vitamin C SagaPart II:Vitamin C and Cardiovascular Health
Is Vitamin C useful in Cardiovascular diseases?
Linus Pauling's specific therapy for cardiovascular and heart diseases was high dosages of two essential nutrients: Vitamin C and the amino acid lysine.
There are evidences of low plasma level of Vitamin C in patients with heart and vascular failure.
In a big analysis thorough 278,459 participants, the relationship of Vitamin C and cardiovascular diseases is explored as follows (1):
Relative risk of CHD (Coronary heart disease) was 0.93 (95% CI: 0.86–1.00) for those consuming three to five servings per day, and 0.83 (95% CI: 0.77–0.89) for those consuming more than five servings per day.
In another clinical study on CVD (cardiovascular disease), patients who received Vitamin C showed a reduction in the arterial stiffness (2).
References:
1. He FJ, Nowson CA, Lucas M, MacGregor GA. Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. J Hum Hypertens. 2007 Sep; 21(9):717-28
2. Ashor AW, Siervo M, Lara J, Oggioni C, Mathers JC .Antioxidant vitamin supplementation reduces arterial stiffness in adults: a systematic review and meta-analysis of randomized controlled trials. J Nutr. 2014 Oct; 144(10):1594-602.
How Vitamin C could help Cardiovascular health?
Vitamin C could help Heart and Vascular system by metabolic balancing and regulation of lipid metabolism. It is well established that Vitamin C inhibits oxidation of LDL-protein (1).
Oxidized LDL has a greater tendency in attachment to scavenger receptors on the endothelial of arteries. And so, Vitamin C can decrease the risk of artery hardening (atherosclerosis) by inhibition of lipid attachment to the arteries (2).
Also Vitamin C is able to prevent apoptosis (programmed cell death) of vascular smooth muscle cells, through it can help keeping formed plaques in the arteries more stable and prevention of plaque detachment and running in the blood stream and increasing the ischemic disorders as heart attack or stroke (3).
Attention!
NOAH Vitamin C as other Nutritional supplements is NOT
for prevention, treatment or diagnosis of diseases.
References:
1. Salvayre R, Negre-Salvayre A, Camaré C. Oxidative theory of atherosclerosis and antioxidants. Biochimie. 2016 Jun; 125:281-96.
2. Li D, Mehta JL. Oxidized LDL, a critical factor in atherogenesis. Cardiovasc Res. 2005 Dec 1; 68(3):353-4.
3. Siow RC, Richards JP, Pedley KC, Leake DS, Mann GE. Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides. Arterioscler Thromb Vasc Biol. 1999 Oct; 19(10):2387-94.
How much Vitamin C should be taken to help Cardiovascular health?
Based on some clinical practice, the recommended dose of vitamin C for its possible benefits in CVD patients is at least 500–1000 mg per day.
Attention!
NOAH Vitamin C as other Nutritional supplements is NOT
for prevention, treatment or diagnosis of diseases.